Endocrine Abstracts

Introduction: National guidance from the Association of Children’s Diabetes Clinicians (ACDC) recommends starting children with newly diagnosed type 1 diabetes mellitus on a total daily insulin dose of 0.5–0.75 iU per kilo per day (kg/d). This equates to a basal insulin dose of between 0.25–0.375 iU/kg per day. Local practice suggested many patients required a significantly smaller starting dose of basal insulin.Ai...

Introduction: The insulin tolerance test (ITT) is the gold standard method to assess GH and/or ACTH deficiency. Safety concerns with the use of this test were raised more than 20 years ago from overtreatment of hypoglycaemia and consequent cerebral oedema, resulting in some centres using alternative tests. We have re-appraised use of the ITT in a contemporary setting and evaluated: i) timing of the glucose nadir, ii) time to resolution of hypoglycaemia, iii) adverse events and...